WHAT IS RAMAN SPECTROSCOPY?
LEARN FROM DR. MARQUARDT
In this video, MarqMetrix Founder & CEO Dr. Brian Marquardt explains what Raman spectroscopy is, talks about its history, details how it works and give some examples of how companies today are using it to improve their processes – in less than 10 minutes!
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DIVERSE INDUSTRY APPLICATION
Raman spectroscopy is used across industries to:
- Measure organic and aqueous samples with minimal to no sample preparation
- Identify chemicals without labels
- Measure without destroying the sample
- Measure solids, powders, liquids, slurries, gas samples
- Provide real-time qualitative and quantitative information in seconds
NEWS & EVENTS
HOW IT WORKS
Our simple-to-use, one-click instrumentation uses a laser as the light source. The sample is illuminated, and the filtered scattered Raman photons are dispersed onto an imaging detector. The intensity of the dispersed photons onto the detector are plotted as a spectrum. The information-rich spectrum contains unique chemical information to determine both chemical identity and concentration.
ADVANTAGES TO RAMAN SPECTROSCOPY
Raman spectroscopy is a well-established vibrational spectroscopy technique for determining both qualitative and quantitative molecular information from almost any type of sample (e.g. solid, liquid or gas). It is highly suitable for real-time process analysis and control applications because it provides direct information, quickly about the chemical bonds that change during reactions or processes. A significant advantage of Raman spectroscopy is that no sample preparation is required and the measurements can be carried out conveniently with immersion or stand-off probe technology.
Raman spectroscopy is a non-destructive, optical measurement technique that allows a sample to be measured multiple times without sample degradation.
If you can see the sample we can measure it with Raman: measurements can be performed through packaging, at distances and at high temperatures and pressures.
Qualitative and quantitative
Raman spectroscopy can be used to quickly, within seconds, identify a molecule’s composition (qualitative) as well as determine the concentration of the molecule (quantitative).
Label-free chemical structure differentiation
Raman spectroscopy accurately measures small changes in material and chemical structure in a wide variety of substances without the need for isotopic or fluorescent labels.
Raman spectroscopy works with many sample types (liquids, solids, slurries, powders, gasses, aqueous). Unlike in Infrared (IR) spectroscopy, water signal does not overwhelm the spectrum.
Raman spectroscopy is indifferent to excitation wavelength
Raman spectra collected on instruments having different excitation sources look very similar. A major advantage when comparing library Raman data acquired using different instruments.
USES OF RAMAN SPECTROSCOPY
The potential of Raman spectroscopy is far reaching. Its label-free, non-destructive nature makes it useful for situations where there is optical access to the sample and chemical analysis is required.
- Track molecule structure changes in materials (including carbon)
- Verify accurate compound and concentration in compounded medicines
- Track crystallinity changes
- Identify substances, including minerals and gemstones
- Identification of molecular polymorphic forms
- Evaluate pressure or stress on a structure
- Assess the direction or orientation of molecules
- Analyze single-cells and tissue for disease diagnosis
- Study molecular hydration shells to determine aggregation