What is Raman Spectroscopy?

What Is Raman Spectroscopy?

Raman spectroscopy is a powerful analytical technique that is widely used for real-time chemical analysis. This technique is based on the Raman effect, which is the inelastic scattering of light by matter. Raman spectroscopy is used to obtain information about the chemical composition and molecular structure of a sample. It is non-destructive, meaning that the sample can be analyzed without any alteration or damage. Raman spectroscopy was first discovered by the Indian physicist Sir C.V. Raman in 1928.

How Does Raman Work?

The Raman effect occurs when a photon of light interacts with a molecule and causes it to vibrate. Some of the photons are scattered in a way that their energy is increased or decreased, which results in a shift in the frequency of the scattered light. This shift is known as the Raman shift and is related to the vibrational energy of the molecule. By measuring the Raman shift, it is possible to obtain information about the molecular structure and chemical composition of a sample.

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In this video, Brian Marquardt, MarqMetrix Founder & CEO, explains what Raman spectroscopy is, talks about its history, details how it works and give some examples of how companies today are using it to improve their processes.


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What Industries Benefit From Raman’s Real-Time Chemical Analysis?

Raman spectroscopy is used in a wide range of industries, including energy, pharmaceuticals, food and beverage, chemical manufacturing, and materials science. 

Energy Industry

  • The energy industry is one of the major users of Raman spectroscopy for real-time chemical analysis, particularly in the field of biofuel production, midstream and downstream oil & gas. Raman spectroscopy is used in two ways:
    1.  To analyze the chemical composition, including the types and amounts of chemical compounds present. This information is essential for optimizing the production process and ensuring the quality of the final product.
    2. To monitor the stability and degradation of refined fuels and biofuels during storage and transportation

Pharmaceutical Industry

  • Raman spectroscopy is used for drug discovery, quality control, and formulation analysis. It is also used to study the interactions between drugs and biomolecules, such as proteins and DNA.

Food & Beverage Industry

  • Raman spectroscopy’s real-time chemical analysis is used for quality control, process monitoring, and quality testing. It can be used to identify the presence of contaminants, and to verify the authenticity of food products, such as wine and olive oil.


  • In cultivated meat production, Raman spectroscopy can be used to analyze the chemical composition of the meat cells and their surrounding environment. This can help to optimize the growth conditions, assess the quality of the cultivated meat, and detect any contamination or unwanted changes in the composition of the product. Additionally, Raman spectroscopy can be used to monitor the differentiation of the stem cells that are used to produce cultivated meat, which can provide valuable information on the development and maturation of the product.

Chemical Manufacturing Industry

  • Raman spectroscopy is used for process control and monitoring. It can be used to monitor the concentration of chemicals in real-time, detect impurities and contaminants, and optimize reaction conditions.

Materials Science Industry

  • Raman spectroscopy is used for process control and monitoring. It can be used to monitor the concentration of chemicals in real-time, detect impurities and contaminants, and optimize reaction conditions.

Raman spectroscopy is a valuable tool for real-time chemical analysis, process control, and materials science, and its applications are likely to continue to grow in the future.

MarqMetrix Raman

Our simple-to-use, one-click Raman measurement instrumentation uses a laser as the light source. The sample isilluminated, and the filtered scattered Raman photons are dispersed onto an imaging detector. The intensity of the dispersed photons onto the detector are plotted as a spectrum. The information-rich spectrum contains unique chemical information to determine both chemical identity and concentration.


Our Raman analyzers are regularly used for real-time chemical analysis in research, product development, process development, manufacturing, process control and quality control in many industries; oil & gas, petrochem & polymers, biotech, pharmaceuticals, food  and beverage, and more.

MarqMetrix is proud to now be part of Thermo Fisher Scientific. Read More